Resident Review Workshop

Thursday, October 14th

8:00 am – 12:00 pm

This workshop is sponsored by

Speaker #1:  Dr. Katherine Hansen, University of California, Davis

Presentation Topic:  Radiation: From basic radiobiology to the technological revolution

Time:  8:00 am – 9:45 am

Presentation Synopsis:  We will go through a basic radiobiology review including a guide to alpha-beta ratios, biologically effective dose, and fractionation schemes. We will also review clinical dose volume histogram evaluation and the structures evaluated for radiation planning (targets vs. organs at risk). We will then apply these concepts to a few clinical radiation practice questions: What are some of the pros and cons of manual planning vs. 3D-planning and inverse planning? How does newer technology (such as positioning devices, on-board imaging, and CT-based planning with IMRT and VMAT) allow us to deliver hypofractionated radiation and/or stereotactic techniques? How does the dose to normal tissues and subsequent side effects different with different radiation delivery and fractionation techniques? What are the capabilities of some different therapy machines on the market?

About the Presenter:  Katherine Hansen is a board-certified radiation oncologist who serves as an associated professor of clinical radiation oncology at the University of California-Davis. She received her DVM from UC Davis in 2013 and then completed a rotating internship at the University of Pennsylvania. After internship, she spent two years as a post-doctoral associated in the radiation oncology labs at Duke University, where she worked on a variety of projects involving murine modeling, hypoxia, and nanoparticle development. She trained as a resident in radiation oncology from 2011-2013, and then signed on as a faculty at UC Davis upon completion of her residency. Her appointment is primarily clinical in nature, and she spends most of her time training residents and treating patients in the clinic. Her research includes collaborations with the UCD-Medical Center physicists on quality assurance and software studies that benefit both human and veterinary radiation oncology. She also publishes on advanced veterinary radiation treatment options, especially in stereotactic radiotherapy.

Speaker #1:  Dr. Travis Laver, University of Georgia

Presentation Title: That’s so basic: A review of signaling pathways in cancer

Time:  10:15 am – 12:00 pm

Presentation Synopsis:  Cellular signaling pathways play a key role in the regulatory network that controls growth and proliferation in normal cells. Dysregulation of these pathways can drive cancer progression via uncontrolled proliferation, evasion of apoptosis, local invasion and more. This session will feature a review of the important physiology that regulates cellular signaling in normal cells. We will then discuss ways in which these pathways become dysregulated and how dependence on these pathways may be exploited in cancer therapy. We will focus our discussion on 4 specific pathways: phosphatidylinositol-3-kinase (PI3K), mitogen activated protein kinase (MAPK), Janus kinase-signal transducer and activator of transcription (JAK-STAT) and Wnt.

About the Presenter:  Dr. Laver received his PhD in cell biology from the University of Alabama-Birmingham where he studied the molecular biology of the human brain tumor glioblastoma multiforme. He went on to receive his VMD from the University of Pennsylvania and subsequently completed a residency in medical oncology at Colorado State University. He is currently a diplomate of the ACVIM in oncology and an assistant professor of oncology at the University of Georgia. He splits his time between the clinical oncology service and his research lab, which focuses on NF-kappaB signaling and proteasome inhibition in a variety of canine and feline cancers.