Resident Review Workshop

Thursday, October 15th

5:45 pm – 8:40 pm (Eastern Time)

This workshop is sponsored by

Speaker #1:  Dr. Jeffrey Bryan, University of Missouri

Presentation Topic:  The concepts of cancer epigenetics and their potential implications for veterinary patients

Time:  6:00 pm – 7:15 pm EDT

Presentation Synopsis:  Cancer is frequently called a genetic disease.  What is often overlooked are the epigenetic contributions to malignancies.  Evidence exists that epigenetic changes precede genetic mutations in many cancers.  Most often in the cancers examined to date, epigenetic abnormalities, or epimutations, greatly exceed sequence mutations in frequency.  While mutations affect the genetic sequence, the hardware of the genetic code, epigenetic marks select genes and chromosomal regions for transcriptional activity, acting as the software that selects and interprets the code to determine cell phenotype.  Epigenetic changes may even lead directly to large mutational events like translocations and contribute to selection of splice variants of expressed genes.  In this lecture, residents will be taught the general forms of epigenetic changes that are known to contribute to gene expression, phenotype, and the malignant condition.  Fundamental concepts will be presented and will be supported by published research describing human cancers to illustrate classic principles.  Epigenetic research in veterinary cancers will be presented to paint our current understanding of these principles in companion animal cancers.

About the Presenter:  Dr. Jeffrey Bryan earned a Bachelor of Science degree in veterinary science from the University of California – Davis in 1991.  He received his D.V.M. from the University of California – Davis in 1993. He worked as an Associate Veterinarian from 1993-1995 and served as Medical Director from 1995-2002 of the Irving Street Veterinary Hospital in San Francisco, CA.  Bryan then completed a medical oncology residency, a Masters of Biomedical Sciences, and a PhD in Pathobiology at the University of Missouri.  He received certification by the American College of Veterinary Internal Medicine in Oncology 2005.  He is the Director of the Tom and Betty Scott Endowed Program in Veterinary Oncology, the Director of PET Imaging Center of the University of Missouri, and the Associate Director of Comparative Oncology for Ellis Fischel Cancer Center.   Dr. Bryan’s research focuses on comparative examination of cancers in companion animals to better understand cancers in all species. His particular areas of interest are targeted imaging and therapy and epigenetics of cancer.  He works with collaborators to develop novel PET imaging agents to better visualize important properties of cancers.

Speaker #1:  Dr. Anne Avery, Colorado State University

Presentation Title: Diagnosis and classification of canine and feline lymphoproliferative disorders

Time:  7:25 pm – 8:40 pm EDT

Presentation Synopsis:  Lymphoproliferative disorders are a highly heterogeneous group of diseases that arise from different stages of lymphocyte development and have widely variable clinical outcomes. The goal of this session is to provide the audience with an understanding of the biological and clinical behavior of a range of canine lymphoproliferative disorders.  The emphasis of the session will be on the most efficient and clinically useful method of diagnosis and classification. The advantages and limitations of cytology, histology and immunohistochemistry, clonality testing and flow cytometry will be presented. While our understanding of feline lymphoproliferative disorders is less well-developed than in dogs, feline small cell intestinal lymphoma has been the focus of intense research recently. Methods for diagnosing this disease and controversies around those methods, will be also be discussed.

About the Presenter:  Dr. Avery is the Director of the Clinical Immunology Laboratory at Colorado State University, and a Professor in the Department of Microbiology, Immunology and Pathology. The primary focus of the Clinical Immunology Laboratory is the understanding of lymphoproliferative disorders at the clinical and molecular level, and how those disorders relate to the normal functions of cells of the immune system. She received her VMD from University of Pennsylvania, a PhD from Cornell, and completed a 3 year post doctoral fellowship at the Dana Farber Cancer Institute in Boston before moving to Colorado State University. The current focus of her laboratory is characterizing the dog as a pre-clinical model for human hematopoietic malignancy.